Carotid Intima-media Thickness as Cardiovascular Mortality Predictor in Peritoneal Dialysis Patients

Carotid Intima-media Thickness and Coronary Flow Reserve as Cardiovascular Event and Mortality Predictors in Peritoneal Dialysis Patients: Results of Seven-year Follow-up From a Single Center

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02938767

Enrollment

Registered

2016-10-19

Start date

2012-01-31

Completion date

2015-01-31

Last updated

2016-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Keywords

peritoneal dialysis, carotid intima-media thickness, coronary flow reserve, cardiovascular mortality

Brief summary

Cardiovascular (CV) disease is the main cause of death in patients on dialysis. The aim of this study is the long-term prognostic values of carotid intima-media thickness and coronary flow reserve in cardiovascular mortality of peritoneal dialysis patients.

Detailed description

Endothelial dysfunction (ED) is a precursor and cause of cardiovascular diseases. Defining of endothelial thickness and coronary microvascular function could be useful for detecting ED. Endothelial dysfunction could be assessed by coronary flow reserve (CFR), carotid intima media thickness (IMT). Repeating measurement of IMT and CFR could be predictor of cardiovascular events and mortality in peritoneal dialysis patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Peritoneal dialysis patients whose followed up at least six months from October 1994 to October 2011 (for study group) * Kidney transplant recipients whose followed up at least six months from October 1994 to October 2011 (for control group)

Exclusion criteria

* diabetes mellitus * valvular heart disease, * any prior coronary intervention and congestive heart failure * Patients whose left anterior descending coronary artery (LAD) could not be visualized adequately by Doppler echocardiography were also excluded.

Design outcomes

Primary

Measure	Time frame
Diseases morbidity	10-15 years

Secondary

Measure	Time frame
Patient Survival	10-15 years

Countries

Turkey (Türkiye)

Outcome results