Adults, BMI>35
Conditions
Keywords
obesity, eccentric exercise, body composition, training program
Brief summary
Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity. The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training). This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition
Detailed description
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).
Interventions
OTHERcycling exercises
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* \- Adults * Obese (BMI\>35) * Inactive (\<10 METS/h/week) * No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity
Exclusion criteria
* (BMI\<35)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in total body fat mass (Dual X ray Absorptiometry) | before and after the 12 weeks training program |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| isometric muscular lower limbs strength | before and after the 12 weeks training program | — |
| isokinetic muscular lower limbs strength | before and after the 12 weeks training program | — |
| rest energy expenditure (indirect calorimetry) | before and after the 12 weeks training program | — |
| biological parameters (plasma lipid profile) | before and after the 12 weeks training program | — |
| aerobic capacities (VO2max) | before and after the 12 weeks training program | — |
| physical activity | before and after the 12 weeks training program | (questionnaires) |
| food intakes | before and after the 12 weeks training program | (measurements) |
| quality of life (questionnaires) | before and after the 12 weeks training program | — |
| segmental body composition | before and after the 12 weeks training program | (segmental fat and fat free mass) |
| biological parameters (insulin-resistance) | before and after the 12 weeks training program | — |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed