Uterine Cervical Cancer
Conditions
Keywords
Locally advanced
Brief summary
This study evaluates the effect of adaptative Intensity-Modulated Radiation Therapy (IMRT) in the treatment of locally advanced cervical cancer on acute genito-urinary (GU), and gastrointestinal (GI) toxicities. Every patients will be treated according to the adaptative IMRT strategy.
Interventions
OTHERAdaptative treatment plan
Each patient will have 3 scanners before treatment initiation. One corresponding to an empty bladder, one to an intermediate one, one to a full bladder.
RADIATIONExternal radiotherapy
At the time of each fraction of external radiotherapy, the most appropriate plan (empty, intermediate, full bladder) covering the target and sparing the organs at risk is chosen.
Sponsors
Center Eugene Marquis
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cervix carcinoma proved by histology * According International Federation of Gynecology and Obstetrics (FIGO) classification, stages IB2, IIA, IIB, IIIA and IIIB without lumbo-aortic lymph node damage (surgical or radiologic) * Patient treated with radio-chemotherapy then curietherapy with curative aim, validated in multidisciplinary meeting * Renal, hepatic and cardiovascular functions that allow administration of the associated systemic treatment * Older than 18 years * Good general status, World Health Organization less or equal to 1 * Signed informed consent
Exclusion criteria
* History of cancer that is not controlled and / or treated for less than 5 years (excepted for cutaneous baso-cellular cancer) * History of pelvic irradiation * Simultaneous participation to another research that could interfere with the study results * Pregnant or breastfeeding patient * Patient under tutor or guardian * Patient not able to respect medical follow-up for geographical, social or psychological reasons * Not affiliated to a system of French social security
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patient having an Acute genito-urinary (GU) and Gastro-intestinal (GI) toxicities assessed by CTCAE V4.03 | 3 months after end of radio-chemotherapy treatment |
Secondary
| Measure | Time frame |
|---|---|
| Number of patient having a Grade ≥ 2 Hematologic and other toxicities assessed by CTCAE V4.03 | 3 months after end of radio-chemotherapy treatment |
Countries
France
Outcome results
None listed