Skip to content

Carbon Monoxide and Oxidative Stress in Waterpipe Smokers

Breath Carbon Monoxide Measurement Predicts Oxidative Stress Which Cause of Deteriorations of Lung Functions in Waterpipe Smokers

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02937415
Enrollment
100
Registered
2016-10-18
Start date
2012-07-31
Completion date
2013-01-31
Last updated
2016-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxidative Stress, Waterpipe Smoking

Keywords

carbon monoxide, oxidative stress, waterpipe smoking, cigarette smoking, pulmonary function test

Brief summary

Waterpipe is a tool for smoking tobacco, which is thought to be less harmful than cigarette. Unfortunately, there aren't adequate studies about its harms to health that are threatening the young generation all over the world today. The objective of this study was to show the carbon monoxide (CO) levels in waterpipe smokers' breaths, whether can be used or not to reflect the changes of oxidative stress for this reason to predict harmful effects on the pulmonary functions.

Detailed description

Waterpipe or hookah uses a different kind of tobacco, which is available in most Balkan countries, Middle East and South Asia. Popularity of smoking waterpipe among European, Canadian, and American young people has shown a dramatic rise over the past decade. The growing popularity of waterpipe use among U.S. teens and adults is evidenced by media reports and the recent rapid proliferation of waterpipe establishments (bars, cafes, or restaurants) in large cities and near college campuses. Typical waterpipes have the following components; a bowl where the tobacco is placed and heated, usually with burning embers or charcoal, a vase or smoke chamber which is partially filled with water, a pipe or stem connecting the bowl to the vase by a tube that carries the smoke down into the water, and a hose with a mouthpiece through which the smoke is drawn from the vase. As the smoker inhales, the tobacco smoke is sucked down from the bowl and then bubbles up through the water into the air of the smoke chamber and then through the hose to the smoker. At the end of a smoking session, the dirty water is thrown away and the waterpipe vase is refilled for the next user. Although each smoking session generally lasts about 45 to 60 minutes, it can also continue for several hours. There is a misconception about smoking waterpipe that it is less harmful than cigarettes, and that's why smoking waterpipe is dramatically increasing especially among young people. While the adverse effects of smoking cigarette are widely described, there are just a few investigations about waterpipe and its effects. This study was designed to investigate the effects of smoking waterpipe on pulmonary functions and oxidative stress parameters.

Interventions

PROCEDUREBreath carbon monoxide

Breath carbon monoxide measurement.

PROCEDUREPulmonary function tests.

Measurement of lung functions by blowing through a tube which measures flow and volumes of participant's lungs.

PROCEDUREOxidative stress and antioxidant status.

Measurement of parameters of oxidative stress and antioxidant status in blood samples.

Sponsors

Ataturk Training and Research Hospital
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Participants who haven't determined major health problems, * between ages 18-40.

Exclusion criteria

* Participants who under age 18 and above 40, * pregnant women, * individuals who have major health problems

Design outcomes

Primary

MeasureTime frameDescription
Breath Carbon Monoxide LevelUp to 4 monthsLevels of CO in breath will be measured in either waterpipe smokers or control group.

Secondary

MeasureTime frameDescription
A spirometric Test; FEV1 (Forced Expiratory Volume in One Second) Measurement.Up to 4 monthsFEV1 Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.
A spirometric Test; FEV1/FVC (Forced Expiratory Volume in One Second/Forced Vital Capacity) Measurement.Up to 4 monthsFEV1/FVC Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.
A spirometric Test; PEF (Peak Expiratory Flow) Measurement.Up to 4 monthsPEF Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.
A spirometric Test; FEF25-75 (Forced Expiratory Flow in 25-75%) Measurement.Up to 4 monthsFEF25-75 Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.
Plasma TAS (Total Anti-Oxydant Status) Measurement.Up to 4 monthsTo Assessment of Anti-Oxidant Status: TAS Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.
A spirometric Test; FVC (Forced Vital Capacity) Measurement.Up to 4 monthsFVC Will Be Measured To Evaluation of Deterioration Levels of Pulmonary Functions in Either Waterpipe Smokers or Control Group.
Plasma OSI Measurement.Up to 4 monthsTo Assessment of Antioxidant Status: TAS (Total Anti-oxydative Status) Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.
Plasma PON (Paraoxonase) Measurement.Up to 4 monthsTo Assessment of Antioxidant Status: PON Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.
Plasma sPON (Stimulated Paraoxonase) Measurement.Up to 4 monthsTo Assessment of Antioxidant Status: sPON Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.
Plasma ARES (Arylesterase) Measurement.Up to 4 monthsTo Assessment of Arylesterase Activity: ARES Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.
Plasma TOS (Total Oxydative Stress) Measurement.Up to 4 monthsTo Assessment of Oxidative Stress: TOS Levels in Plasma Will Be Measured in Either Waterpipe Smokers or Control Group.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026