G6PD Deficiency
Conditions
Brief summary
The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
Detailed description
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed. Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
Interventions
DIETARY_SUPPLEMENTAlpha-lipoic acid
A trial of exercise before and after 4 weeks of alpha-lipoic acid supplementation.
OTHERPlacebo
A trial of exercise before and after 4 weeks of placebo administration.
Sponsors
University of Thessaly
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* G6PD deficiency
Exclusion criteria
* Any uncontrolled health condition for which exercise is contraindicated * Current use of dietary supplements or drugs * Pregnant, pregnancy intention or breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in redox status after exercise | Before, immediately after and 1 hour after each trial of exercise | Indices of blood redox status |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo | Body fat percentage |
| Blood pressure | Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo | Blood pressure at rest |
Countries
Greece
Outcome results
None listed