Parkinson's Disease
Conditions
Brief summary
This study compares the validity and usability of smartphone software for home monitoring of symptoms and signs in Parkinson's disease as compared to the current clinical gold standard - the Unified Parkinsons Disease Rating Scale.
Detailed description
Parkinson's Disease (PD) is a neurodegenerative condition, which when treated can result in fluctuating motor activity - sometimes too much movement, sometimes too little. A series of tests, run on a smartphone, will be used to evaluate the motor signs of Parkinson's and related to a clinical evaluation based on the Unified Parkinson's Disease Rating Scale. 60 participants will be recruited.
Interventions
DEVICECloudUPDRS smartphone software assessment
Smartphone software consisting of a series of tapping and tremor-measurement tests designed to measure a subset of the UPDRS.
OTHERClinical assessment
A clinician will assess the motor signs of the participant using the Unified Parkinson's Disease Rating Scale. The examination will be videoed and rated by 3 blinded examiners.
Sponsors
University College, London
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Diagnosed with probable idiopathic Parkinson's Disease according to Brain Bank criteria (Gibb and Lees, 1988). 2. Over 18 years old. 3. Achieve \>20/30 on the Montreal Cognitive Assessment (MOCA). 4. They must have been on the current Parkinson's Disease medication schedule for at least a week and have no plans to change this during the period of testing. 5. They must have the capacity to consent to take part in the study. 6. They must be able to understand English to the level of being able to operate the phone software, follow its instructions and be able to answer the study questions.
Exclusion criteria
1. Acute medical illness. 2. Any other co-morbidity that in the opinion of the Investigator may preclude their participation in the study. 3. Unable to consent to the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validity of smartphone software for home monitoring in Parkinson's disease | 3 years | The primary objective is to measure the validity (bias and reliability) of the smartphone UPDRS (smartphone derived UPDRS). The primary objective outcome measure is the accuracy (and error) of the smartphone UPDRS predictions of the clinical UPDRS rating score. This will be ascertained by using multiple cross-validation runs in which the data are randomly split into 'calibration' and 'testing' cohorts. The model will be trained on the 'calibration' dataset, and the accuracy and error from the out-of-sample predictions will be summarised into a mean accuracy and error score. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Data exploration | 3years | Data from this study will be subjected to post hoc analysis to explore future hypotheses in this area. |
Countries
United Kingdom
Outcome results
None listed