Vitamin D Supplementation and Respiratory Index of Severity in Children (RISC) in Pneumonia

The Effects of Vitamin D Supplementation in Respiratory Index of Severity in Children (RISC) of Hospitalized Patients With Community-acquired Pneumonia

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02936895

Enrollment

100

Registered

2016-10-18

Start date

2015-01-31

Completion date

2016-09-30

Last updated

2016-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia

Brief summary

Childhood deaths from pneumonia is almost 2000 times higher in developing countries than in developed countries. In 1970, pneumonia was responsible for 9% of all deaths in children under 5 years. This rate was 2% in 2007. Some studies have shown that supplementing with vitamin D reduces disease of the respiratory tract infection. Some other studies have shown anti-inflammatory effect of vitamin D in cell lines. Studies about the role of vitamin D supplementation in pneumonia in children are inadequate to conclude about its role. The aim of this study is to determine the efficacy of vitamin D supplementation in Respiratory Index of Severity in Children (RISC) hospitalized clinical outcomes of hospitalized patients with community-acquired pneumonia.

Interventions

DRUGVitamin D3

vitamin D at a dose of 50,000 IU per day for 2 days

DRUGPlacebo

Placebo for 2 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

2 Months to 6 Years

Healthy volunteers

Inclusion criteria

* Aged between 2 months to 6 years * Definite diagnosis of pneumonia

Exclusion criteria

* Immunocompromised patients * Airway hypersensitivity or asthma * allergies * nasal polyps * Using inhaled medications to one month prior to the study * Receiving high doses of vitamin D * Avoiding to complete informed consent form

Design outcomes

Primary

Measure	Time frame	Description
Respiratory Index of Severity in Children (RISC)	through study completion, an average of 4 days	For determining severity of pneumonia, RISC (Respiratory Index of Severity in Children) scoring system was used, including oxygen saturation, chest retraction, wheezing and refusal to feed, and also contains standards growth (weight for age).

Secondary

Measure	Time frame	Description
Duration of hospitalization	through study completion, an average of 4 days	Duration of hospitalization of the patient

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026