Melatonin
Conditions
Brief summary
The purpose of this study is to examine the effects of complex, broad-band spectra light on the production of melatonin in humans.
Interventions
DEVICELight - standard
Light will be given during the night to determine its effects on melatonin suppression. This light will be an LED with standard spectral distribution
DEVICELight - alternate
Light will be given during the night to determine its effects on melatonin suppression. This light will be an LED with an altered spectral distribution (different color)
Sponsors
VA Palo Alto Health Care System
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Stable health * Normal color vision * Normal hearing * 18-35 years old
Exclusion criteria
* Significant depressive symptoms * Pregnant or nursing * Ocular pathologies * Unstable or severe medical or psychiatric condition * Extreme morning/evening type * Regular smoker * Use of medications that impact ocular function * Alcohol use disorder * Use of illegal drugs * Irregular use of antihistamines, antidepressants, or sleeping medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Melatonin suppression | 4 Hours | The amount of declination of salivary melatonin concentrations between the start of the light and the end of the light (4 hours later) will be compared between the conditions. |
Countries
United States
Outcome results
None listed