Sepsis
Conditions
Brief summary
The aim of this study is to construct multi-center sepsis registry that can be used for data warehousing and clinical research.
Detailed description
This registry prospectively enrolls adult patients with severe sepsis or septic shock in 21 tertiary hospital emergency departments. Registered data can be used for quality control and clinical research to reduce sepsis-related mortality.
Interventions
None listed
Sponsors
Seoul National University Bundang Hospital
Seoul National University Boramae Hospital
Hallym University Kangnam Sacred Heart Hospital
Gangnam Severance Hospital
Kyungpook National University Hospital
Kyunghee University Medical Center
Korea University Guro Hospital
Korea University Anam Hospital
The Catholic University of Korea
Samsung Medical Center
Asan Medical Center
Severance Hospital
Ulsan University Hospital
Inje University Ilsan Paik Hospital
Chonnam National University Hospital
Chonbuk National University Hospital
Jeju National University Hospital
Chosun University Hospital
Hallym University Medical Center
Hanyang University Seoul Hospital
Bucheon St. Mary's Hospital
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* two of more systemic inflammatory reaction syndrome criteria fever \> 38.3 'C or hypothermia \< 36'C, tachycardia over 90 bpm tachypnea over 20 per minute, leukocytosis (WBC over 12k/microL) or leukopenia (WBC below 4k/microL) * suspected or proven infection * any organ dysfunction as follows: 1. cardiovascular (hypotension, systolic blood pressure \<90 mmHg, mean arterial pressure \<70mmHg) 2. tissue hypoperfusion (lactate above upper limits laboratory normal) 3. acute lung injury (PaO2/inspired oxygen fraction \< 250 in the absence of pneumonia, PaO2/inspired oxygen fraction \< 200 in the presence of pneumonia) 4. acute kidney injury (Urine output \< 0.5mL/kg/hr for at least 2 hrs Serum creatinine \> 2.0 mg/dL) 5. acute liver injury (Total bilirubin \> 2mg/dL) 6. acute coagulopathy (Platelet count \< 100,000/μL or prothrombin time, international normalized ratio \> 1.5)
Exclusion criteria
* age less than 18 years old * patients with cardiac arrest at presentation * patients with advanced directives not to deliver aggressive organ supportive management
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28-day | According to hospital discharge record review and telephone follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 90-day mortality | 90-day | According to hospital discharge record review and telephone follow-up. |
| Organ support treatment (mechanical ventilation) | hospital discharge (non-survivors) or 90 days (survivors) | According to hospital record review |
| Organ support treatment (renal replacement therapy) | hospital discharge (non-survivors) or 90 days (survivors) | According to hospital record review |
| ICU length of stay | hospital discharge (non-survivors) or 90 days (survivors) | According to hospital record review |
| Hospital length of stay | hospital discharge (non-survivors) or 90 days (survivors) | According to hospital record review |
Countries
South Korea
Contacts
Primary ContactKyung Su Kim, MD, PhD
Backup ContactWoon Wong Kwon, MD, PhD
Outcome results
None listed