Post Partum Pre-eclampsia
Conditions
Keywords
Post Partum Pre-eclampsia
Brief summary
This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.
Detailed description
Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.
Interventions
OTHERno intervention
database and epigenetic study
Sponsors
New York University
Society for Obstetric Anesthesia and Perinatology
Duke University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Post partum pre-eclampsia Matching based on: * maternal age (years +/-3) * BMI (+/-5 points) * Ethnicity * Mode of delivery * Gestational age at delivery (+/7 days) * Smoking status
Exclusion criteria
* Intrapartum pre-eclampsia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| methylation signature on circulating monocytes | 1 week post delivery |
Countries
United States
Outcome results
None listed