Heart Disease
Conditions
Keywords
TAVI, Aortic stenosis, aortic stiffness, calcifications, CT-scan, Vascular impedance
Brief summary
Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. Despite a high rate of procedural success, some patients do not benefit from the procedure. The investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief. The aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the CT-scan performed systematically before the procedure. This prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (Lyon, Rouen, Paris, Clermont-Ferrand).
Interventions
TAVI is a well-accepted method for aortic valve replacement without surgery. It is currently proposed to patients at high surgical risk or contraindicated to surgery. It consists of introducing a valve inserted inside a stent by the femoral artery in most cases. Aortic calcifications will be determined by the analysis of the CT-scan performed systematically before the procedure. A semi-automated software (CreaTools) will be used
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 * Patient who underwent a transcatheter aortic valve implantation * Patient who provided informed, written consent to participate to FRANCE TAVI study * Patient for whom a CT-Scan performed before TAVI procedure is available.
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular mortality | censored on 3 March 2017 | Number of death of cardiovascular cause will be analyzed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause deaths | censored on 3 March 2017 | Number of death of all causes will be analyzed |
| left ventricular remodeling | censored on 3 March 2017 | Echocardiographic measure will be done |
| left ventricular ejection fraction | censored on 3 March 2017 | Echocardiographic measure will be done |
| diastolic function | censored on 3 March 2017 | Echocardiographic measure will be done |
Countries
France
Outcome results
None listed