Myocardial Infarction
Conditions
Brief summary
The main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2D ultrasound strain after myocardial infarction. Our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase II (or 2D strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. Should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.
Interventions
OTHERCardiac training program
This program takes place at the Cardiovascular Rehabilitation Department at the Nîmes University Hospital and includes a combination of various physical activities: treadmill, exercise bike, rower, aerobics, gymnastics, serious games, swimming. The program begins approximately within 3 months after myocardial infarction and consists of 20 consecutive days of training. The main physical activity is aerobic interval training (AIT). 30-minute AIT sessions will occur 5x per week for 4 weeks. 1 AIT session includes a warm up for 8 minutes to reach a heart rate during exercise corresponding to 20 to 30% of maximum aerobic power determined during the initial effort test. Then interval training occurs with 4x2 min of high intensity effort (heart rate during exercise corresponding to 80% of maximum aerobic power) alternating with 2 min of active recovery at 20-30% of maximum aerobic power. Then recovery for 8 minutes.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * The patient is available for 4 months of follow-up * The patient had a first myocardial infarction episode (within the past 3 months) requiring medical treatment or revascularisation (e.g. balloon angioplasty) or aortocoronary bypass
Exclusion criteria
* The patient is simultaneously participating in (or has participated in the past 3 months) another interventional study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection or under guardianship * It is impossible to correctly inform the patient or the patient refuses to sign the consent * The patient is pregnant, parturient, or breastfeeding * Contra indication for exercise training * Valve prosthesis * Severe valvular disease * Pacemaker * Heart transplant * Non sinus rhythm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The % global longitudinal strain of the left ventricle | within 3 months post infarction = T0 (baseline) |
Secondary
| Measure | Time frame |
|---|---|
| maximum aerobic power (watts) | within 3 months post infarction = T0 (baseline) |
| First ventilatory threshold (mL/min/kg) | within 3 months post infarction = T0 (baseline) |
| left ventricle longitudinal systolic strain rate | within 3 months post infarction = T0 (baseline) |
| left ventricle longitudinal diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| % radial systolic strain | within 3 months post infarction = T0 (baseline) |
| % radial diastolic strain | within 3 months post infarction = T0 (baseline) |
| % circumferential systolic strain | within 3 months post infarction = T0 (baseline) |
| % circumferential diastolic strain | within 3 months post infarction = T0 (baseline) |
| Radial systolic strain rate | within 3 months post infarction = T0 (baseline) |
| Radial diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| maximal oxygen consumption (VO2max; mL/min/kg) | within 3 months post infarction = T0 (baseline) |
| Circumferential diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| Telediastolic volume (mL) | within 3 months post infarction = T0 (baseline) |
| Telesystolic volume (mL) | T0 + 5 weeks |
| Left ventricle mass (g/m^2) | within 3 months post infarction = T0 (baseline) |
| Ejection fraction of the left ventricle | within 3 months post infarction = T0 (baseline) |
| S' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| E' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| A' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| The E/A ratio | within 3 months post infarction = T0 (baseline) |
| Circumferential systolic strain rate | within 3 months post infarction = T0 (baseline) |
Countries
France
Outcome results
None listed