Healthy
Conditions
Keywords
Transcranial magnetic stimulation, Magnetic resonance imaging, Magnetic resonance spectroscopy
Brief summary
This study is a randomized, double-blind, and sham-controlled trial to examine the effects of transcranial magnetic stimulation on the brain of health individuals.
Detailed description
The efficacy of repetitive transcranial magnetic stimulation on the brain will be assessed by multimodal neuroimaging in healthy individuals.
Interventions
DEVICENeurostar TMS Therapy System, NeuroStar XPLOR System
Repetitive transcranial magnetic stimulation
Sponsors
Ewha Womans University Mokdong Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 19-39 years * Informed consent
Exclusion criteria
* Pregnancy or breastfeeding * High fever patient * Current and past history of seizure or epilepsy * Evidence of epilepsy on EEG * Pregnancy or possibility of pregnancy during period * Major medical or neurological illnesses * Evidence of alcohol intake on alcohol breath test * Contraindications to MRI scans and transcranial magnetic stimulation * Risk of skin burns * Use of medications that could have influenced on the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic brain changes in magnetic resonance imaging by computational approaches | after 5 sessions (1 session/day) equals 5 days |
Secondary
| Measure | Time frame |
|---|---|
| Functional brain changes in magnetic resonance imaging by computational approaches | after 5 sessions (1 session/day) equals 5 days |
| Standardized scores on a neuropsychological test battery | after 5 sessions (1 session/day) equals 5 days |
| Analysis of EEG activity | after 5 sessions (1 session/day) equals 5 days |
Countries
South Korea
Outcome results
None listed