Gastrointestinal Stromal Tumor
Conditions
Keywords
DKK4, Gastrointestinal Stromal Tumor, Biomarker
Brief summary
Our study aims to evaluate the role of Dickkopf-4 as biomarkers in the treatment of gastrointestinal stromal tumor.
Detailed description
To identify whether Dickkopf-4 (DKK4) could be a potential biomarker for diagnosis and prognosis in patients with gastrointestinal stromal tumor (GIST). Serum was collected from 50 patients with GIST. Serological levels of DKK4 were examined by enzyme-linked immunosorbent assay (ELISA). The sensitivity and specificity was compared with modified NIH risk criteria. A 3-year follow-up was monitored to evaluate the correlation between DKK4 serum levels and relapse-free or overall survival. The expression of DKK4 in GIST tumor tissues was also evaluated using immunohistochemistry staining.
Interventions
PROCEDUREsurgery or biopsy
Do radical surgery or biopsy to obtain a pathological result
Sponsors
RenJi Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Primary gastrointestinal stromal tumor confirmed pathologically by surgery or biopsy * Age from 18 - 70 years * No serious organic and mental illness;
Exclusion criteria
* Pregnancy * No pathologic result * Suffering other malignancies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Relapse-free Survival | 3 years |
Countries
China
Contacts
Primary ContactHui Cao, PhD
Backup ContactLin Tu, MD
Outcome results
None listed