Effects of Propofol and Ketofol on Core Body Temperature in MRI

Does Magnetic Resonance Imaging Increase Core Body Temperature in Anesthetized Children? Evaluating the Effects of Propofol and Ketofol

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02931786

Enrollment

Registered

2016-10-13

Start date

2014-08-31

Completion date

2016-02-29

Last updated

2018-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children

Keywords

core body temperature, magnetic resonance imaging, propofol, ketofol

Brief summary

Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group, due to its positive effect on thermo regulation

Detailed description

Intravenous anesthetics may impair thermoregulation. Absorption of radiofrequency waves by the body surface may result in heating, especially in small children during magnetic resonance imaging (MRI). Investigators applied two different intravenous anesthetics as propofol and ketamine and studied the effect of these drugs on core body temperature. All patients aged between 6 months-10 years were administered midazolam and atropine. After that 1 mg/ kg of propofol was applied in group I, and 0,1 ml/kg of propofol ketamine mixture ( 10 mg/ml each) was applied in group II. Core body temperatures were taken before and after MRI and compared.

Interventions

DRUGpropofol

propofol, midazolam and atropine administration via intravenous cannula.

DRUGKetamine propofol mixture

Administration of ketamine propofol mixture, midazolam and atropine via intravenous cannula

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

6 Months to 10 Years

Healthy volunteers

Yes

Inclusion criteria

* children aged between 6 months-10 years, * underwent MRI under anesthesia * ASA I-II

Exclusion criteria

* History of drug allergy * Severe pulmonary and cardiac disease * Intracranial hypertension

Design outcomes

Primary

Measure	Time frame	Description
Change in core body temperature	during magnetic resonance imaging (MRI) procedure	temperature was taken from tympanic membrane bilaterally before and after MRI. If temperature change was more or les than 0.1 degrees celsius the patient was considered as warmer or cooler.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026