Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Platelet-rich Plasma
Conditions
Keywords
platelet-rich plasma, endoscopic mucosal resection, endoscopic submucosal dissection
Brief summary
To avoid complications secondary to advanced endoscopic resection techniques (Endoscopic Mucosal Resection -EMR- or Endoscopic Submucosal Disection -ESD-) the endoscopists have to avoid deep thermal damage and increase mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models.
Detailed description
Background:To avoid complications secondary to advanced endoscopic resection techniques (Endoscopic Mucosal Resection -EMR- or Endoscopic Submucosal Disection -ESD-) the endoscopists have to avoid deep thermal damage and increase mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models. Aim: Evaluate the efficacy of PRP on participants submitted to advanced endoscopic resection techniques: EMR or ESD. Material and Methods: The investigators have evaluated a prospective clinical study. The investigators have included 12 participants submitted to EMR or ESD. Patients were informed and accepted to participate with a written consent. Prior to endoscopy PRP was obtained from autologous blood with a comercial kit. Submucosal injection with PRP were performed prior to resection. Resection was performed with standard technique. Participants were followed-up after the procedure.
Interventions
DRUGPlatelet-rich plasma
Submucosal injection with PRP was performed prior to endoscopic resection
Sponsors
Germans Trias i Pujol Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Endoscopic lesion higher than 40mm in diameter submitted to endoscopic resection (EMR or eSD)
Exclusion criteria
* Ineligibility to endoscopic resection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevention of delayed bleeding: percentage of participants with delayed bleeding | 28 days after resection | Delayed bleeding occurs between 13-15% of patients submitted to advanced resection techniques. The aim of this study is to evaluate the efficacy of PRP in the prevention of this complication |
| Prevention of coagulation syndrome (or postpolipectomy syndrome): percentage of participants with coagulation syndrome | 5 days after resection | Coagulation syndrome occurs in around 5-7% of patients submitted to EMR or ESD. The aim is to evaluate the efficacy of PRP in the prevention of this complication |
Countries
Spain
Outcome results
None listed