TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy

Efficacy and Safety of Magnesium Sulfate Added to Local Anesthetic in TAP Block for Postoperative Analgesia Following Total Abdominal Hysterectomy.

Status

UNKNOWN

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02930707

Enrollment

Registered

2016-10-12

Start date

2016-01-31

Completion date

2016-11-30

Last updated

2016-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

magnesium sulfate, postoperative pain, TAP block, total abdominal hysterectomy

Brief summary

Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity. The objective of this study was to detect the efficacy and safety of magnesium sulphate as an adjuvant to the analgesia offered by local anesthetic in ultrasound guided TAP block in patients undergoing total abdominal hysterectomy.

Interventions

DRUGMagnesium Sulfate

ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulfate 10% (200 mg), on each side of the abdominal wall.

DRUGBupivacaine

ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* weight: 50- 85 kg. * ASA score: I-III * scheduled for total abdominal hysterectomy

Exclusion criteria

* history of relevant drug allergy. * coagulation disorders. * opioid dependence. * sepsis. * psychiatric illnesses that would interfere with perception and assessment of pain.

Design outcomes

Primary

Measure	Time frame	Description
total postoperative morphine consumption	postoperative 24 hours	total amount of rescue morphine consumption in the first 24 hours postoperatively

Secondary

Measure	Time frame	Description
postoperative pain	postoperative 24 hours	postoperative pain measured by VAS score recorded in the first 24 hours postoperatively
first request of rescue analgesia	postoperative 24 hours	time to the first requirement of rescue analgesia during the first 24 hours postoperatively
side effects	postoperative 24 hours	occurrence of side effects during the first 24 hours postoperatively

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026