Fabry Disease
Conditions
Keywords
Fabry disease, lucerastat
Brief summary
The primary purpose of this study was to assess the safety and tolerability of lucerastat in adults with Fabry Disease receiving Enzyme Replacement Therapy (ERT). The secondary objectives were to investigate the effects of lucerastat on plasma and urine levels of biomarkers, to assess its effects on renal and cardiac functions and to determine the pharmacokinetic profile of lucerastat at steady-state.
Interventions
DRUGLucerastat
Hard gelatin capsules for oral administration formulated at a strength of 250 mg, and administered as 4 capsules in the morning and 4 capsules in the evening.
All the subjects received an ERT as background therapy for at least 24 months prior to the screening visit and they had to continue receiving this treatment during the conduct of the study.
Sponsors
Idorsia Pharmaceuticals Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signed informed consent form * Male and female adult subjects with a diagnosis of Fabry Disease (FD) based on historical assessments (residual α-GAL A activity level below lower limit of normal for males and presence of a galactosidase alpha mutation for females) and a history of clinical symptoms of FD * On ERT for at least 24 months without any change in dose within the last 6 months prior to screening
Exclusion criteria
* Severe renal function impairment * Severe residual neurologic deficit * Clinically significant unstable cardiac disease * Any circumstances or conditions, which, in the opinion of the investigator, may have affected full participation in the study or compliance with the protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in blood pressure | Up to Week 12 | — |
| Change from baseline in heart rate | Up to Week 12 | — |
| Change from baseline in electrocardiogram (ECG) variables | Up to Week 12 | The duration (in ms) of the different ECG variables were measured using a standard 12-lead ECG |
| Change from baseline in body weight | Up to Week 12 | — |
| Number of subjects with treatment-emergent adverse events and serious adverse events | Up to Week 12 | — |
| Number of subjects with adverse events leading to premature discontinuation of lucerastat or ERT | Up to Week 12 | — |
| Number of subjects with treatment-emergent abnormalities in laboratory variables | Up to Week 12 | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to reach Cmax (tmax) of lucerastat | At Week 4 visit, blood samples drawn at the following time points: pre-dose, 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 6h, 8h, 10h, 12h post-dose | tmax was determined directly from the observed plasma concentration-time curves of lucerastat. Blood samples for PK analyses were drawn at scheduled time points at the Week 4 visit |
| Change from baseline in urine albumin-to-creatinine ratio (UACR) | Up to Week 12 | UACR was used to monitor renal function in subjects with Fabry Disease |
| Terminal half-life [t(1/2)]of lucerastat | At Week 4 visit, blood samples drawn at the following time points: pre-dose, 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 6h, 8h, 10h, 12h post-dose | — |
| Area under the plasma concentration-time curve [AUC(tau)] of lucerastat | At Week 4 visit, blood samples drawn at the following time points: pre-dose, 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 6h, 8h, 10h, 12h post-dose | AUC(tau) corresponds to the area under the plasma concentration time curve of lucerastat over a dosing interval (tau = 12 hours) |
| Change from baseline in plasma biomarkers of Fabry Disease | Up to Week 12 | Biomarkers reflecting glycolipid metabolism were measured (unit of measure: ng/mL) |
| Change from baseline in urine biomarker of Fabry Disease | Up to Week 12 | Biomarker reflecting glycolipid metabolism was measured (unit of measure: ng/mg) |
| Change from baseline in left ventricular ejection fraction (LVEF) | Up to Week 12 | LVEF was used to monitor cardiac function in subjects with Fabry Disease |
| Change from baseline in left ventricular mass index (LVMi) | Up to Week 12 | LVMi was used to monitor cardiac function in subjects with Fabry Disease |
| Change from baseline in estimated glomerular filtration rate (eGFR) | Up to Week 12 | eGFR was used to monitor renal function in subjects with Fabry Disease |
| Maximum plasma concentration (Cmax) of lucerastat | At Week 4 visit, blood samples drawn at the following time points: pre-dose, 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 6h, 8h, 10h, 12h post-dose | Cmax was determined directly from the observed plasma concentration-time curves of lucerastat. Blood samples for PK analyses were drawn at scheduled time points at the Week 4 visit |
Countries
Germany
Outcome results
None listed