The Core Body Temperature Rhythms: Distinguishing MCS From UWS

The Core Body Temperature Rhythms:A Promising Indicator of Distinguishing MCS From UWS

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02930213

Enrollment

Registered

2016-10-12

Start date

2015-01-31

Completion date

2016-06-30

Last updated

2016-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of Consciousness

Keywords

unresponsive wakefulness syndrome, minimally conscious state, circadian rhythms, free-running period

Brief summary

In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .

Detailed description

Living beings have multicomponent biological rhythms. There was a research recorded 24-h virations in electroencephalographic patterns. In normal subjects, the circadian rhythms of core body temperature is close to 24 h. When the interference of environmental and mental elements were eliminated, circadian rhythm shows the endogenous circadian rhythm of body acquiescently (\>24h ), which is also called free-running period. Measuring the continuous external auditory canal temperature of 4 unresponsive wakefulness syndrome (UWS) and 3 minimally conscious state(MCS) on the fluorescent lamp surrounding every 2 hours for 168 hours starting at 00:00 on the first day to address circadian capabilities. Researchers expected to see the difference between MCS and UWS.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

39 Years to 69 Years

Healthy volunteers

Inclusion criteria

* patients in minimally conscious state * patients with stable condition * patients free of sedative drugs and Na+ or Ca++ blockers (e.g., carbamazepine) or NMDA receptor antagonist (e.g., dextromethorphan)

Exclusion criteria

* premorbid neurology antecedent * patients in coma or vegetative state * patients \< 1 months after the acute brain injury

Design outcomes

Primary

Measure	Time frame	Description
Measuring the continuous external auditory canal temperature	Continuous temperature measurements for 168 hours (8days)	VS patients have core body temperature periods which are longer than 24 hours; whereas MCS patients are shorter than 24 hours.

Outcome results