Asthma, Atopy
Conditions
Keywords
farm children, non-farm children
Brief summary
PASTURE is a birth cohort of children born to farm and non-farm women from rural areas across Europe. Five study centres Austria, Germany, Switzerland, France and Finland enrolled 1133 children (farmers in about half of the children) to study the origins of asthma and atopy and to develop potential preventive strategies. Previous results show a protective effect of farm exposure on allergic risk by livestock contacts and microbial exposures and by raw cow milk consumption in early age. PASTURE Part IV is the 10-year follow up of this birth cohort. The primary objective is to characterize the allergic phenotype between 6 and 10 years old (asthma and allergic rhinitis) and to explain how early age exposures and particularly milk products consumption contribute in the process of allergic illness in childhood. A focus on the characterization of the protective biologically active components in raw milk and identification of immunological mechanisms are involved.
Interventions
OTHERblood sampling, skin prick tests, assesment of atopic dermatitis, questionnaires
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 11 Years
Healthy volunteers
No
Inclusion criteria
* PATURE IV is a birth cohort. All children enrolled at the beginning and who still agree to participate will be included at 10-year follow-up.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma | 10 years old |
| Rhinitis | 10 years old |
| Atopic Dermatitis | 10 years old |
| Food Allergy | 10 years old |
| Skin prick tests | 10 years old |
| Specific Immunoglobulin E (IgEs) | 10 years old |
| Blood cytokine profiles | 10 years old |
Outcome results
None listed