Dentine Hypersensitivity
Conditions
Brief summary
Up to date, devices capable of delivering controlled, calibrated, non-contact cold air stimuli in a MR environment are unavailable for quantitative sensory testing. This project therefore aimed at designing and constructing a novel MR-compatible, computer-controlled cold air stimulation device that produces air puffs in a broad flow and cold temperature range. By means of this device, detailed psychophysically testing and subsequent brain scanning of dentine hypersensitivity (DH) subjects will be possible to gain new insights about DH mechanisms.
Interventions
OTHERair puffs
Sponsors
GlaxoSmithKline
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age and between 18 - 60
Exclusion criteria
* Caries * Defective restorations * Full crowns * Orthodontic bands * Bleeding on probing and periodontal pockets deeper than 3 mm * Subjects with gross periodontal disease or treatment of periodontal disease in the past 12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subjective ratings using the BORG scale | May 1, 2016 | individual subject perception ratings will be recorded by means of an adapted BORG scale. For reliability, intraclass correlations will be used covering 3-4 measures within a 3-4-weeks period. |
| blood oxygenation level dependent (BOLD) response | October 1, 2016 | Changes in blood oxygenation level (indirect measure of neural activity) will be recorded |
Countries
Switzerland
Outcome results
None listed