Pain
Conditions
Keywords
craniofacial pain, masticatory muscle, burning mouth syndrome, temporomandibular disorders
Brief summary
The effect of peripheral GABAA receptor activation on pain and sensitivity in healthy human subjects has never been investigated. However, as earlier studies suggest that activation of peripheral GABAA receptors is anti-nociceptive in rats, it is important to determine if these findings can be translated into human subjects to determine if peripheral GABAA receptors are a viable target for future analgesic drug development.
Detailed description
Subproject I This study will test if oral administration of GABA containing solutions will reduce the pain and sensitivity induced by application of capsaicin to the tongue of healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) for the oral cavity study. Subproject II This study will test the hypothesis that intramuscular injection of GABA alone will not be painful, but will reduce muscle pain sensitivity in healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) will be recruited for the intramuscular GABA injection studies Subproject III This study will test the hypothesis that intramuscular injection of GABA with glutamate will decrease the intensity of glutamate-evoked muscle pain in healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) will be recruited for the intramuscular glutamate and GABA injection studies.
Interventions
DRUGGABA oral solution
Oral mouth wash containing either GABA, lidocaine or distilled water will be used to decrease burning tongue pain produced by capsaicin
DRUGIntramuscular GABA
The effect of intramuscular injection of GABA or lorazepam will be compared with buffered isotonic saline
DRUGPain modulation
The effect of GABA alone or in combination with lorazepam on muscle pain produced by intramuscular injection of glutamate will be assessed.
Sponsors
Aalborg University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 20-40 years * Free from ongoing or chronic pain * Adequate conversational English
Exclusion criteria
* Pregnancy or intent to become pregnant, breast feeding * Signs or symptoms of any serious systemic diseases * Current malignancies * High blood pressure * Requirement for chronic administration of psychiatric, analgesic or other medications that might influence their response to pain * Frequent recreational drug or alcohol use * Previous neurologic, musculoskeletal or mental illnesses * Lack of ability to cooperate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Intensity Rating | continuously for 95 minutes | visual analogue scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Jaw Function Tests | every 5 min for 50 minutes | maximal jaw opening, maximal bite force |
| Quantitative Sensory testing | every 10 min for 90 min | Pressure detection and pain threshold, thermal detection and pain threshold |
Countries
Denmark
Contacts
Primary ContactBrian E Cairns, PhD, DrMed
Outcome results
None listed