Motivational Interviewing to Support LDL-C Therapeutic Goals and Lipid-Lowering Therapy Compliance in Patients With Acute Coronary Syndromes: a Prospective Randomized Clinical Study

Conditions

Acute Coronary Syndrome

Keywords

Motivational Interviewing, LDL-C, LDL target, Medication adherence

Brief summary

This study will investigate the impact of motivational interviewing in achieving low-density lipoprotein cholesterol therapeutic targets in patients with acute coronary syndromes.

Detailed description

To determine whether a strategy of enhanced information about the risks of high plasma low-density lipoprotein cholesterol (LDL-C) and the importance of lipid-lowering medication together with close follow-up and motivational interviewing is superior than usual care in achieving LDL-C therapeutic targets, as set by current practice guidelines (LDL-C \<70 mg/dL or \>50% reduction from baseline LDL-C) in patients with acute coronary syndromes.

Olga Kourti, Orestis Konstantas, Ioannis T. Farmakis, Stefanos Zafeiropoulos, Georgios Psarakis et al. (15 authors)

Reviews in Cardiovascular Medicine2022-03-037 citations

10.31083/j.rcm2303081

Predictive Role of Platelet-Associated Indices on Admission and Discharge in the Long-Term Prognosis of Acute Coronary Syndrome Patients

Georgios Psarakis, Ioannis T. Farmakis, Stefanos Zafeiropoulos, Olga Kourti, Orestis Konstantas et al. (18 authors)

Angiology2021-11-1410 citations

10.1177/00033197211052134

Guideline adherence is associated with long-term all-cause mortality in patients after an acute coronary syndrome

I.T Farmakis, Stefanos Zafeiropoulos, Areti Pagiantza, Aristi Boulmpou, Alexandra Arvanitaki et al. (11 authors)

European Heart Journal2020-11-013 citations

10.1093/ehjci/ehaa946.2972

Interventions

BEHAVIORALMotivational Interview

Informational leaflet about the risks of high LDL-C and the importance of adherence to lipid-lowering medication in patients with coronary artery disease. Follow-up motivational interviewing at 1 and 6 months after discharge.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Subject hospitalized for acute coronary syndrome (STEMI, NTEMI or unstable angina) * Subject currently on lipid-lowering therapy or prescribed lipid-lowering therapy at hospital discharge (statins and/or other agents) * Subject who is 18 years or older * Subject or legally authorized representative who is willing and capable of providing informed consent, participating in all associated study activities

Exclusion criteria

* Subject unable to communicate via telephone for study interviewing * Subject with contraindication to statin therapy * Subject with any medical disorder that would interfere with completion or evaluation of clinical study results

Design outcomes

Primary

Measure	Time frame
Achievement of low-density lipoprotein cholesterol therapeutic goal, as specified by current practice guidelines (LDL-C <70 mg/dL or >50% reduction from baseline LDL-C)	12 months after discharge from hospital

Secondary

Measure	Time frame
Overall adherence to lipid-lowering regimen, reported as both a continuous and a binary outcome, by using the 4-item Morisky Medication-Taking Adherence Scale	12 months after discharge from hospital

Countries

Greece

Outcome results

None listed