Glycemic Response
Conditions
Brief summary
Assess impact of potato phytochemical on post-prandial gastric emptying and glucose release from products in a pilot human study.
Detailed description
Preclinical data obtained using an Caco-2 intestinal cell model and enzyme assays suggest phenolic-rich potato extracts decrease intestinal glucose transport. The aim is to determine if these effects extend to the the an in vivo situation. Specifically, the glycemic response following consumption of phenolic rich pigmented potatoes compared to white potatoes with lower phenolic content will be measured. Gastric emptying will also be measured to show the effects are in fact due to rate of carbohydrate digestion and intestinal glucose transport and not gastric emptying rate.
Interventions
OTHERPurple Majesty potato chips
Purple Majesty potato chips
OTHERMountain Rose potato chips
Mountain Rose potato chips
OTHERWhite potato chips
White potato chips
OTHERCrackers
Crackers
Sponsors
PepsiCo Global R&D
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18-25 non-smoker
Exclusion criteria
* BMI outside 18-25 smoker previous gastrointestinal disease or other disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Glucose | up to 2 hours | blood taken at 10, 20, 30, 60, and 120 minutes by finger prick |
| Gastric emptying | up to 4 hours | Breath Hydrogen concentrations will be measured every 15 minutes for 4 hours |
Outcome results
None listed