Interventions for Postoperative Delirium: Biomarker-2 (IPOD-B2)

Conditions

Delirium

Brief summary

The IPOD-B2 Study aims to understand the pathogenesis of postoperative delirium in patients undergoing major surgery. The investigators will identify then correlate soluble biomarkers in blood and cerebral spinal fluid with changes in High Density-Electroencephalogram.

Payne T, Taylor J, Kunkel D, Konieczka K, Ingram F, Blennow K, Zetterberg H, Pearce RA, Meyer-Franke A, Terrando N, Akassoglou K, Sanders RD, Lennertz RC.

2024-10-053 citations

10.1016/j.bjao.2024.100349

Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study.

Taylor J, Parker M, Casey CP, Tanabe S, Kunkel D, Rivera C, Zetterberg H, Blennow K, Pearce RA, Lennertz RC, Sanders RD.

2022-02-08141 citations

10.1016/j.bja.2022.01.005

Reduced Electroencephalogram Complexity in Postoperative Delirium

Sean Tanabe, Maggie Parker, Richard Lennertz, Robert A. Pearce, Matthew I. Banks et al. (6 authors)

The Journals of Gerontology Series A2021-12-0418 citations

10.1093/gerona/glab352

Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies

Margaret Parker, Marissa White, Cameron Casey, David Kunkel, Amber Y. Bo et al. (10 authors)

The Journals of Gerontology Series A2021-07-1444 citations

10.1093/gerona/glab203

Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study.

Ballweg T, White M, Parker M, Casey C, Bo A, Farahbakhsh Z, Kayser A, Blair A, Lindroth H, Pearce RA, Blennow K, Zetterberg H, Lennertz R, Sanders RD.

2020-11-20109 citations

10.1016/j.bja.2020.08.061

Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.

Sanders RD, Craigova L, Schessler B, Casey C, White M, Parker M, Kunkel D, Blennow K, Zetterberg H, Pearce RA, Lennertz R.

2020-11-0417 citations

10.1016/j.bja.2020.10.012

Cohort study into the neural correlates of postoperative delirium: the role of connectivity and slow-wave activity.

Tanabe S, Mohanty R, Lindroth H, Casey C, Ballweg T, Farahbakhsh Z, Krause B, Prabhakaran V, Banks MI, Sanders RD.

2020-06-0189 citations

10.1016/j.bja.2020.02.027

Interventions

PROCEDUREHigh Density-Electroencephalogram

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Adult (\>21 years old) 2. Patients scheduled for an elective open thoracoabdominal aortic aneurysm or TEVAR (thoracic endovascular aortic/aneurysm repair) 3. Requiring spinal drain for surgery that is predicted to stay in two or more days 4. Willing and able to provide informed consent

Exclusion criteria

1. Contraindication for spinal drain 2. Documented history of dementia 3. Unable to communicate with the research staff due to language barriers 4. Individuals who the PI determines are not appropriate for the study such as a history of appointment cancellations. 5. Pregnant or Nursing 6. Prisoners

Design outcomes

Primary

Measure	Time frame
Change from Baseline and correlation between biomarker levels in CSF and HD-EEG changes	Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9

Secondary

Measure	Time frame
Absolute changes in biomarkers in CSF and plasma in delirious and non-delirious patients between baseline and post-operative period	Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9
Correlation between biomarkers in CSF and plasma in delirious and non-delirious patients	Post-operative measure: Up to postoperative day (POD) 9
Absolute changes in activity and connectivity in HD-EEG from baseline to postoperative	Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9
Correlation of biomarkers with the incidence of spinal cord ischemia	Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9

Countries

United States

Outcome results

None listed