Adrenergic Beta-2 Agonist Effect, Albuterol Effect
Conditions
Brief summary
Beta2-mimetics such as Salbutamol have been shown to have ergogenic effects. Acute and chronic inhaled or oral doses of Salbutamol have been shown to increase whole body exercise and muscle performances. The underlying mechanisms are however unclear. Some data suggest that Salbutamol may have some effects on the central nervous system which may explain the improved exercise and neuromuscular performances. The present study aims to assess the effects of acite inhaled or oral Salbutamol intake on the neuromuscular system by using neurostimulation techniques and magnetic resonance imaging.
Detailed description
The effects of Salbutamol intake will be assessed by using transcranial magnetic stimulation on one hand and magnetic resonance imaging on the other hand. Maximal voluntary activation and cerebral activation will be measured during motor tasks performed until exhaustion after acute inhaled slabutamol intake, acture oral salbutamol intake or oral placebo intake.
Interventions
DRUGSalbutamol
Acute intake of Albuterol, a beta2-mimetic, either inhaled or oral.
DRUGPlacebo
Acute oral intake of a placebo drug
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects without respiratory and cordiovascular diseases * Male * Age between 18 and 35 * Trained subjects (\>6 hours of physical activity per week) * Non- or ex-smoker (smoking cessation since at least 1 year)
Exclusion criteria
* Respiratory, cardiovascular and metabolic diseases * Neuromuscular diseases * thyrotoxicosis, or diabetes treated with insulin * alcoholism * MRI contraindication * TMS contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal voluntary activation | Measured immediatly after treatment intake (within 1 h) | Measurement performed by using transcranial magnetic stimulation, superimposed on submaximal and maximal quadricep contractions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cortical activation | Measured immediatly after treatment intake (within 1 h) | Measurement performed by using magnetic resonance imaging and the intensity of the BOLD signal in response to a motor task. |
| Exercise endurance | Measured immediatly after treatment intake (within 1 h) | Time to exhaustion during the exercise muscle test. |
Countries
France
Outcome results
None listed