Ischemic Stroke
Conditions
Brief summary
This is a new vessel wall imaging-based stroke registry which will investigate the clinical utility of the whole-brain intracranial vessel wall Magnetic Resonance Imaging (MRI) technique in assessing the etiologies in patients with ischemic stroke.
Detailed description
The registry will focus on investigating the utility of whole-brain vessel wall MRI techniques in assessing the etiologies in patients with recent ischemic stroke. Patients who have had ischemic stroke (as confirmed by diffusion weighted MRI) and have had or will undergo 3D whole-brain vessel wall MRI within 8 weeks of symptom onset will be recruited into this study. It is anticipated that a total of 1000 subjects will be recruited from Feb 2017 to Feb 2019. Approximately 12 centers in the US and China will participate in the registry. MRI whole-brain vessel wall images will be analyzed for detection and characteristics of various vessel wall pathologies and association between vessel wall imaging findings and patient's clinical information.
Interventions
DEVICEMRI
Contrast-enhanced MRI
Sponsors
Cedars-Sinai Medical Center
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female ≥ 18 years of age * Ischemic stroke onset within 8 weeks and confirmed by diffusion weighted MRI * Ability to read and understand informed consent
Exclusion criteria
* The cause of stroke has been confirmed to be related to cardiac or extracranial carotid or aorta pathologies. * Contraindications to MR imaging including mechanically, magnetically, or electrically activated implants, ferromagnetic implants and ferromagnetic foreign bodies, pregnancy. * Inability to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia. * Non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vessel wall pathology findings by MRI | baseline | To identify vessel wall pathologies such as atherosclerosis, dissection, vasculitis |
Countries
China, United States
Contacts
Primary ContactZhaoyang Fan, PhD
Backup ContactQi Yang, MD, PhD
Outcome results
None listed