Renal Cell Cancer, Renal Cell Carcinoma
Conditions
Brief summary
The incidence of renal cell carcinoma (RCC or kidney cancer) in men exceeds that of pancreatic cancer or leukemia. In women, the incidence of RCC is similar to that of leukemia, ovarian, or pancreatic cancer; thus, RCC is significant health issue. This study focuses on identifying specific molecules \[biomarkers\] of RCC that can be used to develop a reliable low-cost screening method at the point of service. If successful, our method would provide a diagnostic test to distinguish benign kidney masses from malignant ones, eliminating the need to surgically remove a kidney with a benign tumor.
Interventions
None listed
Sponsors
National Cancer Institute (NCI)
Washington University School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients 18 years of age and older undergoing surgery. Patient samples are divided into 2 groups based on their surgery: Patients with an imaged renal mass, encompassing about 300 patients/year (about 1200 total) of both malignant (about 80-85% of time) and benign (about 15-20% of time), and patients with non-kidney cancers, encompassing about 6,000 patients/year (about 24,000 total),
Exclusion criteria
Age \<18 years and prisoners.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine AQP1 | 28 days | Assay results will be compared to the pathology report for the excised renal mass and the ICD10 codes. |
| PLIN2 concentration | 28 days | Assay results will be compared to the pathology report for the excised renal mass and the ICD10 codes. |
Countries
United States
Outcome results
None listed