H.Pylori Eradication Rate
Conditions
Brief summary
After endoscopic resection (ER) of gastric tumors, eradication of Helicobacter pylori (H. pylori) infection is advised to reduce metachronous recurrence. However, few studies have addressed factors influencing H. pylori eradication rates in the aftermath of ER, and none have focused on the optimal timing of therapy to eradicate H. pylori post-ER.Therefore, the investigators will conduct to evaluate whether differences in timing of eradication therapy after ER of gastric tumors.
Detailed description
Uur previous retrospective study unveiled that administering eradication treatment within 2 weeks post-ESD during the active reparative phase of ESD-induced ulcers yielded a markedly higher success rate compared to treatment post-8 weeks during the scarring phase of ESD-induced ulcers.Therefore, we conducted a multicenter, randomized, prospective study to ascertain whether the optimal timing of eradication post-ESD could influence the eradication success rate.
Interventions
OTHEReradication timing
patients who underwent ESD for gastric neoplasms were randomized to receive early (3-5 days) or late (8-9 weeks) H. pylori eradication therapy after ESD.
Sponsors
Gangnam Severance Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. patients underwent endoscopic resection of gastric neoplasm 2. patients who diagnosed as H. pylori infection by rapid urease test
Exclusion criteria
1. Histories of gastric surgery 2. Histories of prior H. pylori eradication therapy 3. Use of drugs affecting H. pylori positivity (proton pump inhibitor, histamine-2 receptor blocker, or antibiotics) within the preceding 2 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| H. pylori eradication rate according to timing of therapeutic regimen after endoscopic resection | The success of H. pylori eradication was determined using a urea breath test conducted 13 weeks ± 5 days after ESD | The success of H. pylori eradication was determined using a urea breath test conducted |
Countries
South Korea
Outcome results
None listed