Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients

Efficacy and Safety of Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients: a Randomized Control Trial

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02921347

Enrollment

Registered

2016-10-03

Start date

2016-09-30

Completion date

2019-12-30

Last updated

2026-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Weaning

Brief summary

The aim of this study is to facilitate weaning by switching between invasive and noninvasive ventilation in difficult-weaning patients.

Detailed description

This study only enrolled patients with tracheotomy. When a patient is eligible to this study, he or she is randomly assigned to intervention or control group.A patient in intervention group is switched to noninvasive ventilation by masking the tracheotomy tube. If the patient presents distress in noninvasive ventilation, he or she is switched to invasive ventilation. If the distress relieves, patient is switched to noninvasive ventilation again until the patient successfully weans from ventilator. In control group, the patient is weaned as the conventional methods.

Interventions

PROCEDUREswitching between invasive and noninvasive ventilation

As defined criteria, patients are switched between invasive and noninvasive ventilation until the ventilator is successfully weaned.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* duration of invasive ventilation ≥14 days * anticipation of difficult weaning * Glasgow Coma Scale ≥13 * no upper airway obstruction * presence of spontaneous breath

Exclusion criteria

* age less than 18 or more than 85 years * contraindications for noninvasive ventilation * anticipation of survival less than 6 months * refusal of tracheotomy

Design outcomes

Primary

Measure	Time frame
ventilator weaning days	from enrollment to 90 days

Secondary

Measure	Time frame
successful weaning rate	from enrollment to 90 days
ICU stay days	from admission to 90 days
hospital stay days	from admission to 90 days
ICU mortality	from admission to 90 days
hospital mortality	from admission to 90 days

Countries

China

Contacts

PRINCIPAL_INVESTIGATORShuliang Guo, MD

First Affiliated Hospital of Chongqing Medical University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026