Ventilator Weaning
Conditions
Brief summary
The aim of this study is early tracheotomy to facilitate weaning by switching between invasive and noninvasive ventilation.
Detailed description
When a patient is eligible to this study, he or she is randomly assigned to intervention or control group.In intervention group,tracheotomy is performed. And then, patient is switched to noninvasive ventilation by masking the tracheotomy tube. If the patient presents distress in noninvasive ventilation, he or she is switched to invasive ventilation. If the distress relieves, patient is switched to noninvasive ventilation again until the patient successfully weans from ventilator. In control group, the patient is weaned as the conventional methods.
Interventions
As defined criteria, patients are switched between invasive and noninvasive ventilation until the ventilator is successfully weaned.
Sponsors
Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* duration of invasive ventilation 5 to 7 days * anticipation of difficult weaning * Glasgow Coma Scale ≥13 * no upper airway obstruction * presence of spontaneous breath
Exclusion criteria
* age less than 18 or more than 85 years; * contraindications for noninvasive ventilation; * anticipation of survival less than 6 months; * refusal of tracheotomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator weaning days | from enrollment to 90 days |
Secondary
| Measure | Time frame |
|---|---|
| successful weaning rate | from enrollment to 90 days |
| ICU stay days | from admission to 90 days |
| hospital stay days | from admission to 90 days |
| ICU mortality | from admission to 90 days |
| hospital mortality | from admission to 90 days |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORShuliang Guo, MD
First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed