Airway Effects of PEEP During Anesthesia Induction.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02920879

Enrollment

120

Registered

2016-09-30

Start date

2016-10-31

Completion date

Unknown

Last updated

2016-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway Management, Anesthesia Induction, Mask-ventilation, Positive End Expiratory Pressure

Brief summary

This study investigates airway effects of PEEP during maskventilation at anesthesia induction. Four patient groups will be ventilated with different PEEP and driving pressures to evaluate time to open airway after start of positive pressure maskventilation during anesthesia induction.

Detailed description

The use of continuous positive pressure (CPAP/PEEP) during pre-oxygenation and mask-ventilation in patients undergoing anesthesia induction is increasing. Continuous positive pressures have several respiratory benefits with well-documented data on both spontaneously breathing patients and intubated patients. However the effects of PEEP on anesthetized patients during mask-ventilation is poorly investigated. In a previous trial the that the investigators conducted, a PEEP-level of 10 cmH2O during mask ventilation after anesthesia induction surprisingly delayed time to alveolar ventilation compared to ZEEP. In order to investigate this phenomenon, four groups of patients will be compared during preoxygenation and mask ventilation after anesthesia induction. Each group consisting of 30 patients will be pre-oxygenated and mask ventilated with different CPAP/PEEP levels and different driving pressures. Time to open airway is measured as number of respiratory cycles until detection of CO2 on the capnograph.

Interventions

PROCEDUREPEEP-level, driving pressure

Different levels of PEEP and different levels of driving pressures during mask-ventilation at anesthesia induction.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

1. ≥ 18- ≤ 65 years male or female. 2. Elective surgery under general anesthesia 3. ASA-classification 1-3 4. Signed and dated informed consent

Exclusion criteria

1. BMI \> 30 2. Predicted difficult mask-ventilation 3. Known hiatus hernia or GERD

Design outcomes

Primary

Measure	Time frame	Description
Time to open airway	20 minutes	Time to open airway depending on ventilatory settings

Contacts

Primary ContactPer Cajander, MD

per.cajander@regionorebrolan.se+46707173663

Backup ContactJohanna Savilampi, PhD

johanna.savilampi@regionorebrolan.se+46706315154

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026