Endothelial Dysfunction
Conditions
Brief summary
The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise
Detailed description
Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting substances produced by the endothelium. An imbalance in these substances limits the ability of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction is a major risk factor for cardiovascular disease. High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two studies that have examined the effect of exercise on endothelial dysfunction induced by high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired flow mediated dilation induced by high-sugar ingestion. Neither study measured important markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin II concentrations, however. In addition, whether the same results apply to older post-menopausal women is unknown. Understanding how acute exercise affects meal-induced endothelial dysfunction in older women is important given that age is related to endothelial dysfunction and cardiovascular disease.
Interventions
OTHERExercise Condition
A bout of exercise in the evening followed by high-sugar meal consumption the following morning
OTHERControl Condition
Rest in the evening followed by high-sugar meal consumption the following morning
Sponsors
Texas Christian University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Post-menopausal women * Must be 45-70 years
Exclusion criteria
* Use of medications or supplements to lose weight * Following a weight loss diet * Smoking * Heavy alcohol consumption * Diabetes * Heart disease * Stroke * Liver disease * Kidney disease * Untreated thyroid disease * Anemia * Uncontrolled hypertension * Pulmonary disease that prevents exercise * Orthopedic problems that prevents exercise * Arthritis problems that prevent exercise * Musculoskeletal problems that prevent exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in brachial artery flow mediated dilation | 0, 60, 120, and 180 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Change in blood endothelin-1concentration | 0, 60, 120, and 180 minutes |
| Change in blood angiotensin II concentration | 0, 60, 120, and 180 minutes |
| Change in blood glucose concentration | 0, 60, 120, and 180 minutes |
| Change in blood nitric oxide concentration | 0, 60, 120, and 180 minutes |
| Change in blood lipoprotein particle numbers | 0, 60, 120, and 180 minutes |
| Change in blood lipid concentration | 0, 60, 120, and 180 minutes |
| Change in blood insulin concentration | 0, 60, 120, and 180 minutes |
Countries
United States
Outcome results
None listed