Benign Prostatic Hyperplasia, Ejaculation, Prostate
Conditions
Keywords
Ejaculation, Benign Prostatic Hyperplasia, Prostate
Brief summary
Every year in France, more than 60 000 people are operated for benign prostatic hyperplasia (BPH). This surgery is accompanied by a change or even a loss of ejaculations externalized what constitutes the main constraint for patients. Empirically, the investigators talk to the patient retrograde ejaculation to explain a possible loss of ejaculation. Yet the underlying mechanism of this modification or loss of ejaculation remains completely unknown. Yet the underlying mechanism of this modification or loss of ejaculation remains completely unknown. No study could not determine whether the predominant mechanism was a real retrograde ejaculation or aspermia. Moreover, technical changes are sometimes tempted to preserve antegrade ejaculation but no scientific rationale can not validate.
Detailed description
Every year in France, more than 60 000 people are operated for benign prostatic hyperplasia (BPH). This surgery is accompanied by a change or even a loss of ejaculations externalized what constitutes the main constraint for patients. Empirically, the investigators talk to the patient retrograde ejaculation to explain a possible loss of ejaculation. Yet the underlying mechanism of this modification or loss of ejaculation remains completely unknown. No study could not determine whether the predominant mechanism was a real retrograde ejaculation or aspermia. Moreover, technical changes are sometimes tempted to preserve antegrade ejaculation but no scientific rationale can not validate.
Interventions
PROCEDURESearch retrograde ejaculation
Sperm count (spz) after orgasm achieved by masturbation will be measured, corresponding to the sum of spz collected in the ejaculate (E) and the first urine after orgasm (U). These measures will be made before surgery (E1 and U1) and after surgery (E2 and U2). The values E1, E2, U1 and U2 will be achieved by multiplying the concentration of spz per unit volume by the total volume of collection.
Sponsors
University Hospital, Limoges
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Man, at least 18 years, which is scheduled for a BPH surgery * Sexually active * Measurement of Residual postvoid less than 6 months * Patients accepting the constraints of the study * Signed Consent * Affiliate or beneficiary of social security system.
Exclusion criteria
* Patients unable to understand the study or to give consent * Patients with known infertility * Patients previously operated prostate * Patients previously treated with a natural prostate treatment (radiotherapy, microwave, radio frequency, ultrasound) * Patients with known urethral stenosis before surgery * Patient with impaired preoperative in ejaculation * Patient under guardianship or under judicial protection * Patient subject to psychiatric care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm count | Baseline and 9 months | Sperm count (spz) after orgasm achieved by masturbation will be measured, corresponding to the sum of spz collected in the ejaculate (E) and the first urine after orgasm (U). These measures will be made before surgery (E1 and U1) and after surgery (E2 and U2). The values E1, E2, U1 and U2 will be achieved by multiplying the concentration of spz per unit volume by the total volume of collection. |
| aspermia (A) | Baseline and 9 months | Aspermia is determined by the ratio of the difference of total spz between before surgery and after surgery on the number of spz before surgery |
| retrograde ejaculation (R) | Baseline and 9 months | retrograde ejaculation is determined by the difference in percentage of retrograde ejaculation between postoperative and preoperative |
| Evaluation of the coefficient C | 9 months | A and R will be subtracted to obtain the coefficient C |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of urinary symptoms questionary (IPSS) before and after surgery | Baseline and 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by changing in urinary symptoms corresponding to the change in score in the evaluation of urinary symptoms questionary (IPSS) before and after surgery |
| Type of surgery | 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by evaluation of the coefficient C depending of type of surgery |
| Degree of resection evaluated by pre/postoperative prostate volume ratio, ratio of prostatic specific antigen (PSA) preoperative / postoperative and measurement of the resected weight (or the number of joules used in case of laser vaporization). | Baseline and 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by assessment of degree of resection |
| Preoperative prostate volume | 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by preoperative prostate volume measurement by ultrasound |
| Evaluation of the coefficient C depending on changing sexual symptoms relating to the change of sexuality questionary (IIEF15) before and after surgery | Baseline and 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by changing sexual symptoms relating to the change of sexuality questionary (IIEF15) before and after surgery |
| Changing in urinary output before and after surgery | Baseline and 9 months | determination of factors influencing the ejaculation changing mechanism after BPH surgery by changing in urinary output before and after surgery |
Countries
France
Outcome results
None listed