Metastasis
Conditions
Keywords
CRC, liver metastasis
Brief summary
The investigators will perform integrative analysis of CRC liver metastasis
Detailed description
The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Interventions
OTHERnormal colorectal tissues
The investigators will extract total protein, DNA and RNA from these groups.
Sponsors
Ganzhou City People's Hospital
Da Fu
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 75 years with histologically proven CRC * No severe major organ dysfunction * WHO performance status of 0 or 1 * No prior cancer chemotherapy
Exclusion criteria
* Age ≥ 76 * Severe major organ dysfunction * World Health Organization (WHO) performance status of \>1 * Prior cancer chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5 years overall survival | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| 5 years disease-free survival | 5 years |
Countries
China
Contacts
Primary ContactDa Fu, Ph.D.
Outcome results
None listed