Infection
Conditions
Keywords
ExtraCorporeal Membrane Oxygenation, patient in intensive care, pharmacokinetic modeling
Brief summary
The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation. The exhibition is evaluated by population pharmacokinetic modeling.
Interventions
OTHERblood sample
Sponsors
Rennes University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 years * Hospitalisation in intensive care * Treatment with ECMO or without ECMO * Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours * With an arterial catheter * Patient Information or their next of kin according to the patients status.
Exclusion criteria
* Pregnancy * Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure exposure to piperacillin | Day 1 | evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPierre Fillatre
Rennes University Hospital
Outcome results
None listed