Lung Cancer
Conditions
Keywords
LCLC; Integrative Analysis; Metastasis
Brief summary
Integrative analysis of LCLC
Detailed description
The investigators will analyzed proteomes of paired normal lung tissues and LCLC with or without liver metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal lung tissue, primary LCLC carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Interventions
OTHERNormal lung tissue
The investigators will extract total protein, DNA and RNA from LCLC patients.
Sponsors
Shanghai Pulmonary Hospital, Shanghai, China
Shanghai 10th People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 75 years with histologically proven LCLC * No severe major organ dysfunction * World Health Organization (WHO) performance status of 0 or 1 * No prior cancer chemotherapy
Exclusion criteria
* Age ≥ 76 * Severe major organ dysfunction * WHO performance status of \>1 * Prior cancer chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5 years overall survival | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| 5 years disease-free survival | 5 years |
Countries
China
Contacts
Primary ContactDa Fu, PhD
Outcome results
None listed