Acute Ketosis
Conditions
Brief summary
This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.
Detailed description
Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken. Placebo: subjects drink saline. Same sampling as on intervention day.
Interventions
OTHER3-hydroxybuturate
Drink of ketone bodies
OTHERPlacebo
Drink of saline
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 20-30
Exclusion criteria
* Smoking * alcohol or drug abuse * Critically ill
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 3-hydroxybuturate | 0-270 minutes | blood level of 3-hydroxybuturate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glucose | 0-270 minutes | Glucose tracer kinetics, endogenous glucose production, muscle biopsy |
| lipid metabolism | 0-270 minutes | Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies |
Countries
Denmark
Outcome results
None listed