Amyotrophic Lateral Sclerosis
Conditions
Brief summary
The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.
Interventions
OTHERPatient Registry
Patient Registry
Sponsors
The Cleveland Clinic
Dartmouth-Hitchcock Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* ALS * Non-neurodegenerative controls * Can willingly give consent * Over 18 years of age
Exclusion criteria
* Cannot give consent * Under 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Questionnaire for Environmental Exposures, Toxins, and Neurological Disease | 1 year |
Countries
United States
Outcome results
None listed