Increase Pregnancy Rate
Conditions
Brief summary
The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately
Interventions
DRUGRecombinant Human Chorionic Gonadotrophin
250 unit intramuscular
DRUGhuman chorionic gonadotrophin + gonadotrophin releasing hormone agonist
250 unit intramuscular + 1 mg subcutaneous
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. Infertile couples wishing to do intracytoplasmic injection trial . 2. first intracytoplasmic injection trial 3. Body mass index:18-30. 5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone \>1 ng/ml
Exclusion criteria
1. Azoospermic male. 2. Body mass index more than 29. 3. Patients with endometriosis . 4. Antimullerian hormone \< 1 ng/ml
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of M II oocytes in both groups | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Fertilization rate in each group | 3 days |
| Clinical pregnancy rate in each group | 15 days |
Countries
Egypt
Outcome results
None listed