Intraoperative Neurophysiological Monitoring
Conditions
Keywords
Spectroscopy, Transcranial Doppler, Bispectral index, Cardiac surgery
Brief summary
Multimodal brain monitoring is feasible and can be used in formulating therapeutic strategies during cardiac surgery. Such monitoring may help to improve patient outcome and to reduce costs after cardiac surgery with CPB.
Detailed description
The aim of this study is to use a combination of brain monitoring {Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), bispectral index (BIS)} to formulate therapeutic strategies based on these monitors and to evaluate the impact on patient outcome.
Interventions
DEVICENearinfrared Spectroscopy (NIRS)
Patients will be monitored and interference will be done to optimize the medical condition based on such monitor
Patients will be monitored and interference will be done to optimize the medical condition based on such monitor
DEVICEBispectral index (BIS)
Patients will be monitored and interference will be done to optimize the medical condition based on such monitor
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Elective cardiac surgery with cardiopulmonary bypass * Valve replacement * Coronary artery bypass
Exclusion criteria
* Emergency surgery * Hepatic * Renal impairment * Diabetes Mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| S100 protein | up to 24 hours | S100 protein (marker of brain injury) |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state examination | up to 30 days after surgery |
| Western perioperative neurological scale | up to 30 days after surgery |
| Major neurological out come as stoke | up to 30 days after surgery |
| Duration of mechanical ventilation | up to 30 days after surgery |
| Hospital stay | up to 30 days after surgery |
Countries
Egypt
Contacts
Primary ContactMohamed Ali, PhD. MD
Backup ContactSayed K Abd-Elshafy, MD
Outcome results
None listed