Acute Kidney Injury
Conditions
Keywords
acute kidney injury, cardiovascular surgery, mortality
Brief summary
Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.
Detailed description
Acute kidney injury (AKI) after cardiovascular surgery remains a serious complication associated with increased mortality for up to 10 years. The incidence of AKI after cardiovascular surgery is as high as 55% and the incidence of renal replacement therapy (RRT) to be up to 8 %. Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.
Interventions
Patients who underwent cardiovascular surgery including valve replacement or thoracic aortic surgery with cardiopulmonary bypass
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients who underwent cardiovascular surgeries with cardiopulmonary bypass (CPB), including valve replacement and surgery on the thoracic aorta at the Seoul National University Hospital between 2007 and 2015
Exclusion criteria
* Missing preoperative serum creatinine (sCr) values * Missing preoperative platelet, neutrophil and lymphocyte counts * Patients who underwent preoperative hemodialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury | postoperative day seven | acute kidney injury during postoperative seven days defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | postoperative seven years | all-cause mortality after cardiovascular surgery after postoperative seven years |
Other
| Measure | Time frame | Description |
|---|---|---|
| Postoperative length of hospital stay | postoperative two month | postoperative length of hospital stay |
| Postoperative length of ICU stay | postoperative two months | postoperative length of ICU stay during postoperative two months |
| Postoperative incidence of complications | postoperative two months | postoperative incidences of surgery-related complications during hospital stay |
Countries
South Korea
Outcome results
None listed