Chronic Obstructive Pulmonary Disease
Conditions
Keywords
alpha-1 antitrypsin deficiency, pulmonary rehabilitation, exercise training, skeletal muscle biopsy
Brief summary
In a former study, the investigator observed significant differences in the response to pulmonary rehabilitation between COPD patients with the normal genetic variant of alpha-1 antitrypsin (PiMM) and those with a homozygous deficient variant (PiZZ) (Jarosch et al., 2016, DOI: 10.1159/000449509). PiZZ COPD patients showed less improvement in exercise capacity compared to PiMM patients. This latter finding was mirrored by an increase of oxidative myofiber type I proportion - that is important for aerobic exercises in daily life - in PiMM but not PiZZ patients. Based on this finding of impaired skeletal muscle adaptation, the aim of this study is to compare the effects of pulmonary rehabilitation including exercise training on a) specific enzymes of energy metabolism reflecting the oxidative capacity of the skeletal muscle and b) the analogue gene expression of these oxidative enzymes in a cohort of PiMM and PiZZ COPD patients.
Interventions
PROCEDUREPulmonary rehabilitation
3-weeks of inpatient pulmonary Rehabilitation including exercise Training (daily endurance and strength Training)
Sponsors
CSL Behring
Schön Klinik Berchtesgadener Land
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Chronic obstructive pulmonary disease * phenotype PiMM or PiZZ * written informed consent
Exclusion criteria
* any comorbidities that prevent patients from participating in an exercise Training program * necessity of anticoagulant therapy * other genetic variants of alpha-1 antitrypsin than PiMM or PiZZ
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endurance time | 3 weeks | Will be measured during a constant work rate cycling test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Myofibre type I Distribution | 3 weeks | Skeletal muscle sample will be taken from the M.vastus lateralis via Bergström muscle biopsy needle |
| Capillary to fibre ratio | 3 weeks | Skeletal muscle sample will be taken from the M.vastus lateralis via Bergström muscle biopsy needle |
| muscle strength | 3 weeks | strength test in the right knee Extensor and flexor |
Countries
Germany
Contacts
Primary ContactInga Jarosch
Outcome results
None listed