The Relationship Between Structure and Visual Function in Myopia Foveoschisis

Correlation of Structural and Visual Function Changes in Myopia Foveoschisis Patients Undergoing Macular Buckle Surgery

Status

Suspended

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02915133

Enrollment

Registered

2016-09-26

Start date

2016-10-31

Completion date

2021-09-18

Last updated

2019-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Myopia

Keywords

high myopia, myopia foveoschisis, macular buckling

Brief summary

Macular foveoschisis (MF) is a common complication of pathological myopia, which is characterized by choroid-retinal degeneration and vision impairment. Although pars plana vitrectomy (PPV) is the primary method for MF treatment, there is still a large proportion of recurrent MF due to the extremely long global axial length and posterior staphyloma. Macular buckling (MB) surgery aims at counteracting the traction exerted by the posterior staphyloma, and has been proven an effective method for treating MF. Optical Coherence Tomography (OCT) is widely used for the structural analysis of MF. Multifocol electroretinogram (mfERG) is an objective examination for visual evaluation. To our knowledge, there is a lack of data on the comprehensive visual function evaluations of MF patients associated with OCT findings. Our clinical trial aims to provide the structural and functional relationship in MF patients undergoing MB surgery, and find out potential factors to determine the visual prognosis.

Interventions

PROCEDUREmacular buckling surgery

Participants with high myopia foveoschisis are scheduled to macular buckling (MB) surgery.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. axial length ≥ 26.5 mm or refractive error (spherical equivalent) ≥ 8.0 diopter; 2. macular foveoschisis that requires surgical intervention.

Exclusion criteria

1. ocular trauma or surgery history; 2. glaucoma, diabetic retinopathy; 3. intraocular active hemorrhage or inflammation; 4. unable to coordinate the OCT, mfERG, or other ophthalmological examinations.

Design outcomes

Primary

Measure	Time frame
change from baseline OCT at 6 months	6 month postoperatively
change from multifocal ERG at 6 months	6 month postoperatively

Secondary

Measure	Time frame
change from Best-corrected visual acuity (BCVA) at 6 months	6 month postoperatively

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026