Acute Kidney Injury, Liver Injury, Inflammation
Conditions
Brief summary
The investigators hypothesize that subjects undergoing liver resection and who are exposed preoperatively to high illuminance blue spectrum light will exhibit reduced organ injury, specifically liver dysfunction, than subjects exposed to standard ambient white fluorescent light.
Interventions
OTHERBlue light
Illumination: High illumination lighting will be instituted with a Day\*Light Classic Light (Uplift Technologies, Dartmouth, NS) Blue wavelength: Each subject will be fitted with blue filtered goggles (Lee Filters, Burbank, CA). These goggles ensure the transmission of a bright (1700 lux) blue (peak 442 nm) spectrum light when the subject is within 12 inches. Photoperiod: A 24-hour photoperiod will be used that commences at 0800 the morning prior to surgery and continues for 24 hours. To account for potential variability in the exposure of interest, each subject will complete a diary to catalogue duration and distance of light exposure. Postoperatively the same photoperiod will be instituted and continued for one 24 hour period.
Sponsors
National Institutes of Health (NIH)
University of Pittsburgh Medical Center
University of Pittsburgh
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age greater than 17 years * undergoing right or left hepatic lobectomy
Exclusion criteria
* presence of acute traumatic brain injury * blindness * immunosuppression or immunocompromised condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline creatinine concentration at 24 hours after surgery | preoperatively and 24 hours after surgery | a serum marker of acute kidney injury |
| Change from baseline alanine aminotransferase (ALT) concentration at 24 hours after surgery | preoperatively and 24 hours after surgery | a serum marker of acute liver injury |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ICU length of stay | for the duration of postoperative inpatient hospital stay up to 28 days | — |
| Change in serum cytokine concentrations at 24 hours after surgery | 24 hours after surgery | serum will be analyzed for cytokines and inflammatory mediators |
| Change in serum cytokine concentrations at 1 hour after surgery | 1 hours after surgery | serum will be analyzed for cytokines and inflammatory mediators |
| renal replacement therapy | for the duration of postoperative inpatient hospital stay up to 28 days | — |
| Ventilator-free days | for the duration of postoperative inpatient hospital stay up to 28 days | — |
Countries
United States
Outcome results
None listed