Cognitive Impairment, Sepsis
Conditions
Brief summary
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?
Interventions
None listed
Sponsors
Karolinska University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Male/Female age 18-17 * Expected ICU-stay more than 24 hours
Exclusion criteria
* Dont understand the language * Substance abuse, alcohol or drugs * Blind, deaf or suffering from aphasia * Ongoing psychiatric illness or psychopharmacological treatment * Suffering from dementia och mentally impaired * Structured brain damage or meningitis * Palliative Care * ICU-treated for more than 48 hours * Transferred from other ICU * Being treated with ECMO * Not having residency in Stockholm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is HMGB1 elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? | 2 years |
| Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis? | 4 years |
Countries
Sweden
Outcome results
None listed