Analgesia, Hepatectomy, Nerve Block
Conditions
Brief summary
This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al. between unilateral continuous quadratus lumborum block (QLB) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
Interventions
PROCEDUREContinous QLB (quadratus lumborum block)
Inject local anesthetics in between quadratus lumborum and psoas major muscle with catheter insertion and continuous local infusion
The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scan
DRUGRopivacaine
* 0.6ml/kg 0.5% ropivacaine with 1:200,000 adrenaline given immediately after the correct position of the tip of the needle has been verified. * followed with 0.2% ropivacaine infusion at a rate of 0.125ml/kg/h given through the catheter inserted in between the quadratus lumborum muscle and psoas major muscle.
Bolus: 1-2mg, lock time: 10min, 1h limitation: 5-10mg. without background infusion.
Sponsors
Cui Xulei
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo hepatectomy with right J-shape subcostal incision * Informed consent
Exclusion criteria
* A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative morphine consumption | at 24 postoperative hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The pain scores determined by the numeric rating scale (NRS, 0-10) | At 0, 2,4, 8, 12, 24 ,48,72 hours and 7 day after the surgery | — |
| Nausea and Vomiting score | At 0, 2,4, 8, 12, 24 and 48 hours after the surgery | — |
| Pruritus score | At 0, 2,4, 8, 12, 24 and 48 hours after the surgery | — |
| Postoperative hospital length of stay | Up to 6 weeks | — |
| Time of recovery of bowl movement | within the 7 days after surgery | — |
| Quality of recovery | 3 days and 7 days after surgery | use the self-assessment 11 item QoR scale to assess the patient's recovery quality |
| Patient satisfaction with anesthesia | 48 hours after surgery | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia |
| Ambulation time | within the 7 days after surgery | — |
Countries
China
Outcome results
None listed