Hypotension
Conditions
Brief summary
Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, the investigators evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section.
Interventions
DRUGOndansetron
DRUGNormal saline
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Undergoing an elective lower segment caesarean section.
Exclusion criteria
* Patients with contraindications to subarachnoid block (patient refusal, unstable haemodynamics, coagulation abnormality), * History of hypersensitivity to ondansetron or local anaesthetic agents, * Hypertensive disorders of pregnancy, * Cardiovascular insufficiency, * Receiving selective serotonin reuptake inhibitors or migraine medications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypotension | intraoperative | Systolic BP \<90 mmHg or Diastolic BP \<60 mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bradycardia | intraoperative | HR \<50 beats/min |
Countries
Egypt
Outcome results
None listed