Cataplexy, Narcolepsy
Conditions
Keywords
Idiopathic hypersomnia, heart rate variability, parasympathetic activity, autonomic arousal response
Brief summary
Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia. Drug-free patients diagnosed with idiopathic hypersomnia and age-matched controls were included. Clinical data, 24-h polysomnography, heart rate variability and the heart rate response to spontaneous arousal are analyzed.
Interventions
DEVICEPolysomnography
The polysomnography, for both groups, was performed accordance with standard practice
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Idiopathic hypersomnia patients * idiopathic hypersomnia diagnosis * complaints of excessive daytime sleepiness for \>1 year * a night-time length \>10 h for 3 weeks before polysomnography as assessed by a sleep diary Inclusion Criteria: no idiopathic hypersomnia patients * no sleep complaints and excessive daytime sleepiness (Epworth sleep questionnaire score \<10
Exclusion criteria
(both): * Narcolepsy-cataplexy * sleep irregularities and sleep deprivation symptoms * lack of neurological or psychiatric diseases * upper airway resistance syndrome * periodic limbs movements * cerebral lesion * medication or drinks affecting sleep and wake state
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| High Frequencies (HF) | During the polysomnography (one night) | Nocturnal parasympathetic activity (HF parameter of heart rate variability analysis) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability (HRV) | During the polysomnography (one night) | HRV is measured by the polysomnography. It is a composite outcome : Standard Deviation of NN intervals (SDNN), the proportion of NN30 (and 50) divided by total number of NNs (pNN30, pNN50), Root Mean Square of Successive Differences (RMSSD), Standard Deviation type 1 and 2 (SD1, SD2), Low Frequencies (LF), Very Low Frequencies (VLF), LF/HF ratio and Ptot indexes |
| Apnea-Hypopnea Index (AIH) | During the polysomnography (one night) | — |
| Epworth Sleepiness Scale (ESS) | Before the polysomnography (one night) | It examines eight different situations using a 4-grade scale ranging from 0 (no chances of napping) to 3 (high chances of napping). Subjects were defined as sleepy if they had an ESS\>10 |
Countries
France
Outcome results
None listed