Salivary Bacterial Profiles in Relation to Periodontal Treatment

Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02913248

Enrollment

Registered

2016-09-23

Start date

2016-10-31

Completion date

2017-01-02

Last updated

2017-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

periodontitis, saliva, bacteria

Brief summary

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

Detailed description

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Interventions

PROCEDUREConventional periodontal treatment

Non-surgical periodontal treatment including thorough instruction in self-performed oral hygiene

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 99 Years

Healthy volunteers

Inclusion criteria

\- Manifest chronic periodontitis according to international classification

Exclusion criteria

* Other treatment requiring oral conditions * Systemic antibiotics within the latest 6 months * Systemic diseases and medications with known associations to periodontitis * Pregnancy and breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
Changes in α-diversity in saliva samples collected .	Baseline and 12 weeks	Comparison of α-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment

Secondary

Measure	Time frame	Description
Specis specific changes in saliva samples collected	Baseline and 12 weeks	Comparison of relative abundance of bacterial species in saliva samples collected before periodontal treatment to samples collected 12 weeks after treatment

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026